When an American soldier in Italy during World War II starts writing letters for his unsophisticated friend to a woman they have never met, the woman falls in love with the author of the letters, setting in motion a life-changing sequence of events for all three of them.

An amnesiac man found wandering in the Texas desert works to reconstruct his past with the help of his wife and family who have not seen him in four years.

Blonde Betty Elms has only just arrived in Hollywood to become a movie star when she meets an enigmatic brunette with amnesia. Meanwhile, as the two set off to solve the second woman's identity, filmmaker Adam Kesher runs into ominous trouble while casting his latest project.

When Robert Langdon wakes up in an Italian hospital with amnesia, he teams up with Sienna Brooks, a doctor he hopes will help him recover his memories. Together, they race across Europe and against the clock to stop a madman from unleashing a global virus that would wipe out half of the world's population.

In the third season, Weller finally tracks down Jane, who's been on the run. After the two discover her new hidden tattoos, Jane is forced to return to the FBI, where Weller, Jane, and the rest of the team set out to solve these new puzzles and stop the dangerous conspiracies they reveal.

A beautiful woman is found naked in Times Square, her memory erased, her body covered in a series of coded tattoos. But as 'Jane Doe' and the FBI team who discovered her work to decipher, investigate, and solve the complex treasure map of her body, an ever-widening web of conspiracy and corruption is revealed, as is the truth behind Jane Doe's real identity and the identity of the people who sent her to the FBI in the first place.