George is a very successful stand-up comedian who learns that he has less than a year to live. Ira, who is a struggling up-and-coming comedian works at a deli. One night the two perform at the same club, and George decides to make Ira his best friend. This lopsided relationship gradually takes on aspects of true friendship as Ira forces George to try to reconnect with the people in his life, including his ex-girlfriend Laura.

Abandoned by his mother at the age of 8, Marcel is raised by his loving grandfather, Pascual. But when he turns 21 and prepares to move out, starting a new life with his girlfriend, he must choose between caring for Pascual, who has become sick with old age, and pursuing his dreams and desires.