Abby, a savvy, witty veterinarian who hosts her own radio talk show, is anything but confident when it comes to love. A petite brunette, she describes herself as tall and blonde when Brian, a caller who is smitten with her radio persona, asks her on a date. She then talks her tall, blonde neighbor Noelle into assuming her identity, setting off an escalating series of hilarious and romantic crises.

A look at the top-secret, high-tech espionage war going on between cats and dogs, which their humans are blissfully unaware of. The film follows Mr. Tinkle's (a cat) plan to destroy a new vaccine, that if developed, would eliminate all human allergies to dogs, and allow cats to rule the world. Lou, a beagle puppy accidentally becomes the dog-agent assigned to stop the cat plan.