Two middle-class American homebodies on vacation in Mexico on a long-awaited fishing trip decide to pick up a hitchhiker who turns out to be a killer. Suddenly their car and their very lives are commandeered by a psychopathic serial killer.

In April 1992 a young man from a well-to-do family hitchhiked to Alaska and walked alone into the wilderness north of Mt. McKinley. His name was Christopher Johnson McCandless. He had given $25,000 in savings to charity, abandoned his car and most of his possessions, burned all the cash in his wallet, and invented a new life for himself. Four months later, his decomposed body was found by a moose hunter. How McCandless came to die is the unforgettable...

Eddie Valpolicella, is on his way from Massachusetts to Arkansas to give a talk on "his" novel, Breakfast with Buddha, when, not far from home, he picks up a mysterious hitchhiker. Plainly dressed, insisting that he's a fan of the author, the hitchhiker claims to be Jesus, the Jesus, and accompanies Eddie on a five-day road trip that challenges him in an amusing variety of ways.

Film director John Waters hitchhikes across America from Baltimore to San Francisco, braving lonely roads and treacherous drivers.

Horror film depicting a young man's attempts to escape from and later apprehend a psychopathic killer he picked up hitchhiking in the desert.

"July 1995. April and Eddie have taken a wrong turn. They're looking for the small resort town where they plan to spend their honeymoon. When they spot what appears to be a lone hitchhiker along the deserted road, they stop to help. But not long after the hitchhiker gets into their car, they see the blood seeping from her jacket and a truck barreling down Atticus Line after them. When the hitchhiker dies at the local hospital, April and Eddie find...