Primetime television's most riveting hour hits new heights as secrets of the past come to light and critical choices shape the future. While Callie and Arizona examine their relationship, Dr. Herman delivers staggering news that will rock the hospital to its core. Meanwhile, Derek leaves Meredith to discover the ultimate truth, and Maggie's shocking announcement proves that blood is thicker than water.

It's a year of new beginnings for the medical team of Seattle Grace Hospital as they slowly recover from the tragedy that hit too close to home. New relationships emerge and the strongest commitments are tested. From successes in the operating room to mistakes in the bedroom - and all the thrilling drama in between, the doctors find a way to survive as long as they lean on one another.

After being on her own for some time, Meredith is beginning to explore the idea of a romance with Riggs. Unfortunately, Maggie desires him as well, which threatens to drive a bitter wedge between the sisters. At the same time, despite their differences, Jackson and April must come together when they are assigned a difficult case. Meanwhile, Alex faces the consequences of his vicious attack on DeLuca, Owen and Amelia's marriage implodes and a hospital-wide...