This film traces the sexual triumphs and disasters of two American men as it traces their lives from college days to middle age.

The series proves how seemingly trivial details of one's day-to-day life, a trip to the grocery store, a remark at a dinner party, a fender-bender, can precipitate a 'Murphy's Law' chain of misfortune to hilarious effect. To keep the narrative spontaneous, Curb is shot without a script; cast members are given scene outlines and often improvise lines as they go.