Neighbors Nutmeg the squirrel and Barley the mouse believe that they have nothing in common until an emergency forces them to discover surprising things about each other.

Raccoon does not want to be alone on a stormy night but his neighbors, Possum, Quail, and Woodchuck, each tell him they have no room to spare.

Although Jacob finds his autistic brother, Nathan, annoying, he gets angry at a new neighbor who calls Nathan weird, but their mothers help the boys get along with a special Hanukkah observance.

Soon after her beloved grandmother's death, Trisha's family moves to a diverse California neighborhood where she meets Stewart and his grandmother, Miss Eula, who brings people together to help a grieving neighbor.

Delsie loves tracking the weather, living with her grandmother, and the support of friends and neighbors, but misses having a "regular family," especially after her best friend outgrows her.