Ramona Quimby, one of the most loved characters in children's fiction, has now reached third grade. At school, she acquires a new teacher, Mrs. Whaley, who addresses the class as "you guys." At home, she helps the family "squeak by" as her father returns to college to become an art teacher. All the Quimbys have their ups and downs, but none feels them more intensely than Ramona. Her low point is undoubtedly reached the day she throws up in class...

Beezus' biggest problem is her 4-year-old sister Ramona. Even though Beezus knows sisters are supposed to love each other, with a sister like Ramona, it seems impossible.

The family routine is upset during Ramona's year in second grade when her father unexpectedly loses his job.

Recently, Ramona Quimby has been following Henry Huggins on his newspaper route, embarrassing him in front of his customers and his friends. The day Ramona follows Henry to his "No girls allowed" clubhouse, she almost puts an end to his newspaper career forever.

Henry Huggins gets carried away with his own ambitions when he longs for a paper route of his own, and gets some unexpected help from the irrespressible and inescapable Ramona Quimby.