Ramona Quimby, one of the most loved characters in children's fiction, has now reached third grade. At school, she acquires a new teacher, Mrs. Whaley, who addresses the class as "you guys." At home, she helps the family "squeak by" as her father returns to college to become an art teacher. All the Quimbys have their ups and downs, but none feels them more intensely than Ramona. Her low point is undoubtedly reached the day she throws up in class...

Maggie resists learning cursive writing in the third grade, until she discovers that knowing how to read and write cursive promises to open up an entirely new world of knowledge for her.

Follows the adventures of nine-year-old Ramona at home with big sister Beezus and baby sister Roberta and at school in Mrs. Meacham's 4th grade class.

Ramona meets many interesting people in kindergarten class, like Davy whom she keeps trying to kiss and Susan whose springy curls seem to ask to be pulled.