Having changed the course of human history after unwittingly wondering what could be worse than going to prison, George and Harold are catapulted through time back to their kindergarten days, where they are subjected to a sixth-grade bully and a cluelessschool principal.

George and Harold have really done it this time--they've created a monster! She's faster, smarter, and more evil than anything the world has seen before--she's Wedgie Woman! With the help of her horrible robots and her horrendous hairdo, Wedgie Woman is on a mission to take over the world, and she'll give a whopping wedgie to anyone who stands in her way--including Captain Underpants.

George, Harold, Captain Underpants, and Sulu the bionic hamster battle the three ridiculous Robo-Boogers in an attempt to turn the Bionic Booger Boy back into Melvin Sneedly.

When Professor Pippy P. Poopypants comes to Jerome Horwitz Elementary School to teach science, and he goes off the deep end because students make fun of his name, only Captain Underpants can save the school from the professor's perilous plot. Por burlarse del nombre del profesor Pipicaca, Jorge y Beto están a punto de hacer que su nuevo maestro de ciencia enloquecido de rabia se apodere del planeta entero. Pero Capitán Calzoncillos viene al rescate....

Jorge y Berto han creado un monstruo, la Supermujer Macroelástica. Con la ayuda de sus horripilantes robots y su horrendo mono, la Supermujer está dispuesta a apoderarse del mundo y administrarle un golpe a todo el que se interponga en su camino-- incluido el Capitán Calzoncillos. George and Harold have really done it this time-- they've created a monster! She's faster, smarter, and more evil than anything the world has seen before--she's Wedgie...