When a sinister substitute teacher takes over their class, it is up to Eugene and the rest of the Sunnyview Superhero Squad to find Ms. Beasley and foil the sub's plot.

After learning about Sherlock Holmes, Humphrey the classroom hamster follows clues to try and discover why Mrs. Brisbane is gone and Mr. E, a fun but not very educational substitute, is taking her place in Room 26 at Longfellow School.

Cam's photographic memory helps a scatterbrained substitute teacher, especially when he discovers that he has misplaced his coat.

When his long-lost uncle dies, leaving him his supervillain business, Charlie, as rich, soulless predators backed by multinational corporations and venture capital come after him, finds going bad looking pretty good with unionized dolphins, hyperintelligent talking spy cats and a terrifying henchperson at his side.

Sixth-grader Jake Ali Mathews is slowly settling in at his new school and has a new best friend, Michael, but a substitute teacher arrives who instructs by having her students help with a fledgling pet-grooming company, which strains his friendship and tests his growing popularity.

"Keep your friends close and your enemies closer! When Snowball, the puffball hamster in Ms. Kim's classroom, accidentally sips the teacher's leftover protein shake, she transforms into a monster like Beacher Elementary School has never known before. It's all hands on deck to stop Snowball before it's too late. And to do that, Milton Worthy is going to do have to team up with Noah, the part-time classroom ferret, full-time evil mastermind! Will Milton...

When her substitute teacher realizes she is struggling in math, Judy is sent to a math tutor at the local college and soon is completely into the spirit of college life.