FBI agent Sean Archer (John Travolta) must go undercover to investigate the location of a lethal biological weapon planted by his arch rival, terrorist-for-hire Castor Troy (Nicolas Cage). After undergoing a radical surgical procedure, Archer literally "borrows" Troy's face and identity to carry out his mission. But things go awry when Troy, emerging from a coma, is transformed into Archer and wreaks havoc upon his life, both at work and at home.

Now working at a private security firm in Berlin, Carrie is trying to start a new life, but she soon discovers she can't escape her past. Blindsided by stunning betrayals, and without Saul and Quinn to rely on, Carrie must uncover a deadly conspiracy that puts thousands of lives at risk, including her own.