Based on William Brinkley's popular novel, it chronicles a global catastrophe that nearly decimates the world's population. Because of its positioning, the Navy destroyer U.S.S. Nathan James avoided falling victim to the devastating tragedy. But now the crew and its captain must confront the reality of their new existence in a world where they may be among the few remaining survivors.

Jim is an infirmary patient who wakes up from a coma to find an empty room, in a vacant hospital, in the deserted city of London. A powerful virus, which locks victims into a permanent state of murderous rage, has transformed the world around him into a seemingly desolate wasteland. He runs into a mob of crazed plague victims. He gradually finds other still-human survivors with whom he heads off across the abandoned countryside to find the source...