Struggling with wacky family activities, secrets, and feuds, private investigator Isabel Spellman avoids Henry Stone by spending time drinking with his mother and tackling eccentric cases that seem suspiciously pointless.

Targeted by the members of her dysfunctional family for control over Spellman Investigations after staging a retaliatory takeover, Izzy is wrongly accused of embezzling funds from a wealthy Alzheimer's patient.