After their plane crashes on an isolated tropical island, the survivors discover others who are descendents of a secret medical testing group called the Dharma Initiative. As the power of the island to both heal and destroy comes into sharp focus, the lines between good and evil are blurred and loyalties are challenged when the survivors of the crash become tangled within the lives of the Others.

Dorothy Gale lives with her Aunt Em and Uncle Henry. She has a pet dog named Toto. When Miss Gulch takes Toto away, Toto escapes and runs back to Dorothy. Soon, she runs away from home, and runs into the fake psychic, Professor Marvel. He tells Dorothy that her Auntie Em is sick, so Dorothy and Toto run back home, but a tornado comes and takes Dorothy and Toto to Oz, a place somewhere over the rainbow. She lands in Munchkinland. Her house accidentally...

During this exciting pivotal season: Clark faces rogue Kryptonians, Lex Luthor launches a vicious political campaign, the Fortress of Solitude rises, Clark's love for Lana Lang deepens and he and Lois Lane remain friendly adversaries, Clark crosses paths with AC (aka Aquaman), Victor Stone (aka Cyborg) and the mysterious Milton Fine (aka Brainiac).