Innocence and flesh were sacrificed when two young brothers ignored the laws of Alchemy in an attempt to resurrect their mother. In an era of war and corruption, State Alchemist Edward Elric and his brother Alphonse desperately search for the Philosopher's Stone. The legendary artifact is their last hope to restore what was lost - or it could be their undoing. The grisly truths found in the quest for the relic will test their souls in ways unimaginable....

After their plane crashes on an isolated tropical island, the survivors discover others who are descendents of a secret medical testing group called the Dharma Initiative. As the power of the island to both heal and destroy comes into sharp focus, the lines between good and evil are blurred and loyalties are challenged when the survivors of the crash become tangled within the lives of the Others.