Eleven-year-old Barry Hunter and his family attempt to ride out Hurricane Katrina at home in the Lower Ninth Ward in New Orleans when his little sister gets ill, but when the levees break, Barry gets swept away from his family.

When the mysterious first aid kit takes golden retriever Ranger to New Orleans shortly before Hurricane Katrina hits, he finds himself helping Clare Porter and her grandmother, who are waiting for Clare's father at their home in the Lower Ninth Ward--andwhen the levees break and Clare is separated from Nana, Ranger must somehow get her to the relative safety of the Superdome, and reunite her with her family.