A recently widowed grandmother is determined to grant her husband's last wish, that she set his ashes free over the idyllic bluff they called Annie's Point. When her son Richard refuses to let his mother make the two thousand-mile trip, she takes off anyway with her free-spirited granddaughter in tow.

A bicyclist is kidnapped from the Tour de France by mysterious gangsters; his grandmother travels to the city of Belleville (which has a sardonic version of the Statue of Liberty in its harbor), where she tracks him down with the help of a musical trio gone to seed, the Belleville Triplets.

George decides that his grumpy, selfish old grandmother must be a witch and concocts some marvelous medicine to take care of her.

Orphans Sabrina and Daphne Grimm are sent to live with an eccentric grandmother that they have always believed to be dead.

Although Juno, a Korean American boy, cannot read the letter he receives from his grandmother in Seoul, he understands what it means from the photograph and dried flower that are enclosed and decides to send a similar letter back to her.

Gabby convinces Granny to leave Sleepytown and stay up all night in a new place, but before long, a contagious yawn takes control.

"Eleven year-old Peter Lee has one goal in life: to become a paleontologist. But his summer falls apart when his real-life dinosaur expedition turns out to be a bust, and he watches his dreams go up in a cloud of asthma-inducing dust. Even worse, his grandmother, Hammy, is sick, and no one will talk to Peter or L.B. about it. Perhaps his days as a scientist aren't quite behind him yet. Armed with notebooks and pens, Peter puts his observation and...

Claudia's participation in the Baby-sitters Club is curtailed when Grandmother Mimi suffers a stroke and Claudia finds herself "Mimi-sitting" and fighting more frequently with her sister.