Dr. Peter Blood, an Irish physician, had a wide ranging career as a sailor and as a soldier, before settling down to practice medicine in the town of Bridgewater. The town begins to fight for the Duke of Manmouth, and though Peter wants no part in the rebellion, he tends to the wounded soldiers. Because of this he is convicted to treason, and sentenced to death by hanging. King James II, for purely financial reason, decides to sell the criminals as...

Struggling to support her father's medical practice in 1935 rural Alaska, Gwyn falls for her sister's fiancé, Jeremiah, who has been secretly working for Gwyn's father after unfairly losing his medical license.

Remembering childhood stories her grandfather once told her, young physician Natalia becomes convinced that he spent his last days searching for "the deathless man," a vagabond who claimed to be immortal. As Natalia struggles to understand why her grandfather, a deeply rational man would go on such a farfetched journey, she stumbles across a clue that leads her to the extraordinary story of the tiger's wife.